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In many cases HSP70s can function redundantly All of the cellular activities of HSP70s depend on their ATP regulated ability to interact with exposed hydrophobic surfaces of proteins Herein focus is given on the regulation function and disease relevance of the molecular HSP70 chaperones as well as their impact as therapeutic drug targets
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HSP70 Function Based on Cellular Localization
Under physiological conditions HSP70 family members function as molecular chaperones in an ATP dependent manner Depending on their cellular localization HSPs mediate different functions Intracellular residing HSP70s protect cells against lethal damage induced by stress and support folding and transport of newly synthesized polypeptides and
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Jan 23 2007 Molecular chaperone that promotes the maturation structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction Undergoes a functional cycle linked to its ATPase activity This cycle probably induces conformational changes in the client proteins thereby causing their activation
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